Description
Why Irdabisant as a H3 antagonist
- Out of the tested doses (20/80/240/500 mcg), 20 mcg is the best and higher doses leads to undesirable effects [x]
- Continuing the last study to see which is the best of the lower doses, out of the tested doses (5/25/125 mcg), 25 mcg is the best [x]
- Irdabisant has much higher affinity at H3 (Ki = 2.0 nM) than ABT-239 (Ki = 9.1 nM) and Ciproxifan (Ki = 85.9 nM) [x]
- Irdabisant has a long 24.7 hr half-life in humans [x]
BCP